Role of necroptosis in spinal cord injury and its therapeutic implications

Spinal cord injury (SCI), a complex neurological disorder, triggers series of devastating neuropathological events such as ischemia, oxidative stress, inflammatory events, neuronal apoptosis, and motor dysfunction. However, the classical necrosome, which consists receptor-interacting protein (RIP)1, RIP3, mixed-lineage kinase domain-like protein, is believed to control novel type programmed cell death called necroptosis, through tumour necrosis factor-alpha/tumour factor receptor-1 signalling or other stimuli. Several studies reported that necroptosis plays an important role in neural damage, release intracellular pro-inflammatory factors, lysosomal dysfunction endoplasmic reticulum stress. Recent research indicates crucial pathophysiology number disorders SCIs. In our review, we summarize potential regulated by SCI based on its molecular pathophysiological mechanisms. We also targets several pathways, provide more reliable reference for treatment SCI.